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买伽马-羟丁酸 或 γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug. It is a precursor to GABA, glutamate, and glycine in certain brain areas. It acts on the GHB receptor and is a weak agonist at the GABAB receptor. GHB has been used in the medical setting as a general anesthetic and as a treatment for cataplexy, narcolepsy, and alcoholism. It is also used illegally as an intoxicant, as an athletic-performance enhancer, as a date-rape drug, and as a recreational drug.
It is commonly used in the form of a salt, such as sodium γ-hydroxybutyrate (NaGHB, sodium oxybate, or Xyrem) or potassium γ-hydroxybutyrate (KGHB, potassium oxybate). GHB is also produced as a result of fermentation, and is found in small quantities in some beers and wines, beef and small citrus fruits.
GHB is used for medical purposes in the treatment of narcolepsy and, more rarely, alcoholism, 虽然仍有不确定性有关其效力相对于其他药物治疗酒精依赖性。 It is sometimes used off-label for the treatment of fibromyalgia. GHB是有效成份的处方药羟丁酸钠(Xyrem). 羟丁酸钠是经美国食品和药物管理局用于治疗有关的猝倒与嗜睡症 and excessive daytime sleepiness (EDS) associated with narcolepsy.
GHB has been shown to reliably increase slow-wave sleep and decrease the tendency for REM sleep in modified multiple sleep latency tests.
The FDA approved labeling for sodium oxybate suggests no evidence GHB has teratogenic, carcinogenic or hepatotoxic properties. Its favorable safety profile relative to ethanol may explain why GHB continues to be investigated] as a candidate for alcohol substitution.
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