Onsolis (Fentanyl) [Buckal Lösliga Film] 600mcg

Onsolis (Fentanyl) [Buckal Lösliga Film] 600mcg

Onsolis (Fentanyl) 600mcg buccal soluble films:
Onsolis (Fentanyl) behandlar svår, pågående smärta som inte kan kontrolleras med andra läkemedel. Detta läkemedel är ett narkotiskt smärtstillande medel.
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DESCRIPTION

Onsolis (fentanyl buccal soluble film) is an oral transmucosal form of the potent opioid analgesic, fentanyl citrate, intended for application to the buccal mucosa. Onsolis uses the BioErodible MucoAdhesive (BEMA™) bilayer delivery technology which is comprised of water-soluble polymeric films. Onsolis consists of a printed white bioadhesive layer bonded onto a white inactive layer. The active ingredient, fentanyl citrate, is incorporated into the bioadhesive layer, which adheres to the moist buccal mucosa. The amount of fentanyl delivered transmucosally is proportional to the film surface area. It is believed that the inactive layer isolates the bioadhesive layer from the saliva, Onsolis (Fentanyl) 600mcg,which may optimize delivery of fentanyl across the buccal mucosa.

Active Ingredient

Fentanyl citrate, USP is N-(1-Phenethyl-4-piperidyl)propionanilide citrate (1:1). Fentanyl is a highly lipophilic compound (octanol-water partition coefficient at pH 7.4 is 816:1) that is freely soluble in organic solvents and sparingly soluble in water (1:40). The molecular weight of the free base is 336.5 (the citrate salt is 528.6). The pKa of the tertiary nitrogens are 7.3 and 8.4. Fentanyl citrate has the following structural formula:

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