Metadon 20 mg

Buy Methadone 20mg Online, Methadone 20mg is an opioid analgesic synthesized in 1937 by the Germans Max Bockmühl and Gustav Ehrhart (IG Farben) who were looking for an analgesic that would be easier to use during surgery and thus, Have less potential for addiction. The methadone molecule has a chiral carbon atom – C6 which carries 4 different substituents – it is therefore in the form of two enantiomers:

(R) -metadon
(S) -metadon
Der er differentiable af deres modsat roterende strøm. Den form, der anvendes i behandlingen er racemisk, der er 50:50 blanding af de to former.

Metadon 20 mg har været anvendt siden 1960 som en erstatning for opiater i heroin-brugere under ledelse af Vincent Dole. Dens anvendelse har været lovligt i Frankrig siden 1995. I almindelighed, den blanding af D-og L-isomere, der er anvendt, selv om den aktivitet, der søges overført, er næsten udelukkende på grund af L-form. Som et narkotisk smertestillende, metadon bruges til at Lindre stærke smerter.

According to the legislation in force in each country, the prescription of methadone may be subject to the laws on the prescription of psychotropic substances.buy Methadone 20mg online

Absorption
Metadon 20 mg absorberes hurtigt i mave-tarmkanalen, og de første smertestillende effekt vises efter 15 til 30 minutter i sirup og 1 til 1h30 i kapslen. Varigheden af handling er seks til otte timer. På gentagen administration, virkningsvarighed og half-life (15 til 55 timer) også stige.

The plasma therapeutic level of methadone is approximately 100-400 μg · l-1 (micrograms/liter) and the toxic plasma level is about 1,000 to 2,000 μg · l-1 (micrograms/liter).

Stofskifte
Metadon 20 mg is mainly metabolized in the liver by mono- and di-N-demethylation and then spontaneously converts to a cyclic structure, on the one hand, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP, Methadone primary metabolite) and 2-ethyl-5-methyl-3,3-diphenylpyrrolidine (EMDP, secondary metabolite) on the other hand. Methadone is also metabolized by hydroxylation to methadol, followed by N-demethylation to normethadol. Methadone, EDDP, and EMDP also undergo hydroxylation followed by glucuronidation. The major metabolites of methadone are inactive

Substitutionsbehandlinger

I en 2011 undersøgelse af 292 kliniske eksperter i Skotland, metadon blev placeret som nummer 12 for personskade og 10 for samfundsmæssig skade på 19 nuværende rekreative drugs3.
Uddybende artikel: Opiat behandling.
Indført i Usa i 1960'erne af Dole og Nyswander4, var de første, der anvendes til alvorlige heroin-misbrugere, som for soldater, der vender tilbage fra Vietnam.

The aim of the medication is to substitute the consumption of opiates for a euphoric effect (heroin, morphine and certain analgesics) to help the person stabilize his cravings5. Together with medico-social care in the context of a withdrawal cure, methadone treatment aims to stabilize the person’s addiction and harm reduction. The aim of this medicalization is to reduce the risks inherent in drug use: the risks associated with the injection of intravenous substances or nasal administration (including HIV and hepatitis C), risks Overdose or overdose, and risks associated with illegal activities to obtain heroin (deal, prostitution). Moreover, when a person is under methadone treatment, they will experience virtually no euphoria if they consume heroin. This discourages many consumers from relapsing. The introduction of medication can be an integral part of a global process of abstinence.

Methadone 20mg has the advantage of being a long-acting opiate, preventing the sensation of lack and relapse of heroin use. It is taken orally, in one dose per 24h and in some cases two doses per 24h for short “metabolizers”, in the form of a bitter and non-injectable solution, capsules or suppositories. In general, the syrup is in the liquid formula of 1% methadone hydrochloride: 1 ml of solute represents 10 mg of methadone hydrochloride.

Medicinske anbefalinger angiver en sædvanlig maksimal daglig dosis på 60 mg per 24 h6. Undersøgelser i Schweiz har vist, at nogle patienter har brug for højere doser på 80 mg, 200 mg eller 250 mg ved starten af behandlingen 7. Den maksimale dosis recept kan være begrænset af love om levering af psykotrope stoffer, afhængigt af landet.

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